4.9 stars - based on 27 reviews

iS Clinical

Hydra-Cool Serum


"I’m all about multitasking products, and this hydrating serum is one of my favorites. Not only is it lightweight and deeply moisturizing, but it’s also amazing for calming redness. I recommend it for all skin types, especially those with dehydrated or oily skin, blemishes, or rosacea."

This plant-powered hyaluronic acid serum refreshes all skin types with both cooling and hydrating properties. For dry skin, it can be layered under moisturizer for an extra layer of hydration. Those with oily skin can use it in place of moisturizer. Menthol helps calm excess heat and reduce redness due to factors like rosacea, sun exposure, or irritation from shaving or skin care.

Size: 1 fl oz / 30 ml

Please Note: This product is only available to ship within the United States at this time.

Retinol Reform

Complimentary Retinol Reform & Intensive Eye Cream Minis w/ any $150 order.


How to Use

Can be used AM and/or PM. After cleansing, toning, and your usual treatment (Vitamin C or Retinol) apply a fuller dropper of serum—or enough to smooth over face and neck. Follow with moisturizer and/or sunscreen, if needed. Can also be used as a spot treatment to soothe sunburn or razor burn.

Formulated Without

  • Parabens
  • Silicone
  • Dimethicone

Key Ingredients

Centella Asiatica:

Powerful antioxidant with nourishing properties that helps diminish signs of aging

Hyaluronic Acid:

Nature's most powerful hydrator, hyaluronic acid binds moisture to the skin for lasting hydration

Mushroom Extract:

Helps minimize the appearance of uneven skin tone while brightening the overall complexion

Vitamin B5:

Has anti-inflammatory and hydrating properties


This serum is perfect to use during travel—it really helps counteract in-flight dehydration—as well as to reduce redness when your skin is acclimating to a new product, like retinol.


A favorite of Shani’s A-list clients, iS Clinical is known for its physician-grade, plant-powered formulas that target acne and signs of aging.
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