4.8 stars - based on 43 reviews

iS Clinical

Active Serum


"When my clients are struggling with blemishes, I immediately point them towards this serum. It works fast to deliver clearer, brighter skin—and unlike most acne treatments, it also helps minimize signs of aging.”

iS Clinical’s most popular product and a physician favorite, Active Serum provides both rapid and long-term relief of blemishes. It helps clarify and shrink the appearance of pores with an array of gentle, yet powerful exfoliating ingredients—including botanical forms of salicylic, lactic, and glycolic acids—while at the same time working to smooth, even out skin tone, and minimize fine lines and wrinkles. This formula is suitable for pregnant and nursing women, making this a powerful anti-blemish and anti-aging pick for any age or stage of life.

Size: 1 fl oz / 30 ml

Please Note: This product is only available to ship within the United States at this time.

Retinol Reform

Complimentary Retinol Reform & Intensive Eye Cream Minis w/ any $150 order.


How to Use

Can be used AM and/or PM. After cleanser and toner, apply 3-4 drops of serum—or enough to smooth over face and neck. The tingling sensation is completely normal and should dissipate in a few minutes.

Formulated Without

  • Parabens
  • Silicone
  • Dimethicone

Key Ingredients

Sugar Cane Extract:

Botanical source of Glycolic Acid which gently exfoliates the skin for a renewed complexion.

Bilberry Extract:

Botanical source of Lactic Acid, a gentle exfoliant with moisturizing properties

White Willow Bark Extract:

Botanical source of Salicylic Acid, which exfoliates the skin and deep-cleanses pores

Arbutin & Mushroom Extract:

Helps minimize the appearance of uneven skin tone


I often recommend this serum for my clients who can’t use retinol—but Active Serum and Retinol Reform also work beautifully together. Just use them on alternate nights to keep blemishes in check.
Shop Retinol Reform


A good skincare routine combines multiple actives (like Vitamin C, Retinol and Salicylic Acid) between AM and PM for the most optimal results. The best delivery system? Potent serums that deliver targeted benefits.