4.9 stars - based on 17 reviews

iS Clinical

Super Serum Advance+


"A great vitamin C serum should be part of everyone’s morning skincare routine. I love this one because it doesn’t just help protect skin from UV rays and pollution—it also helps heal existing skin damage, including scars, fine stretch marks, uneven skin tone, and wrinkles.”

This lightweight serum is ideal for those seeking brighter, younger looking skin. It combines two powerful ingredients for aging in reverse: a 15% concentration of advanced L-ascorbic acid (vitamin C) to protect skin from environmental damage, and a bioidentical Copper tripeptide growth factor to assist with skin healing. It also contains botanical antioxidants and safe skin brighteners to help improve the look of dark spots and raised scars and visibly diminish uneven skin tone.

Size: 1 fl oz / 30 ml

Please Note: This product is only available to ship within the United States at this time.

Retinol Reform

Complimentary Retinol Reform & Intensive Eye Cream Minis w/ any $150 order.


How to Use

Can be used AM and/or PM. After cleanser and toner, apply 3-4 drops of serum—or enough to smooth over face and neck.

Formulated Without

  • Parabens
  • Silicone
  • Dimethicone

Key Ingredients

L-Ascorbic Acid:

A scientifically-advanced, highly stable form of vitamin C, which helps to calm and protect against the visual effects of UV damage.

Arbutin & Mushroom Extract:

Helps minimize the appearance of uneven skin tone while brightening the overall complexion.

Copper Tripeptide Growth Factor:

Clinically proven to help diminish the appearance of wrinkles, skin damage, and other signs of aging over time.

Centella Asiatica:

Powerful antioxidant that helps diminish scarring and signs of aging.


If you’re using retinol—which makes skin more sun-sensitive—a vitamin C serum like this is a must. Apply it in the morning under sunscreen for antioxidant protection throughout your day.


A favorite of Shani’s A-list clients, iS Clinical is known for its physician-grade, plant-powered formulas that target acne and signs of aging.
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